****** DATA-MÉDICOS *********

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MELANOMA Y CABALLOS

MELANOMA AND HORSES

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***** DERMAGIC-EXPRESS No 12 ******* 

****** 02 NOVIEMBRE 1.998 ******* 

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 EDITORIAL ESPAÑOL

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Hola amigos dermágicos, en el correo de hoy en la LISTA DERMLIST de Brasil (Dr. George leal), quien muy gentilmente publica las ediciones de DERMAGIC, ví una pregunta interesante, la Dra. Clara Jaramillo de Colombia Pregunta por melanoma en caballos. Espero que no sea cabellos. Me fui a la NET y conseguí 9 referencias interesantes, allí se las mando.,,, 

Dr. Robert Pribyl, gracias por su comentario, seguiré adelante mientras la motivación exista, saludos,,, 

Dra. Jaramillo, esta recibiendo la edición de DERMAGIC, directamente a su dirección electrónica, todavía tengo la duda sobre su pregunta, cabello o caballos ???. La busque como melanoma y caballos, si se trata de cabellos, tampoco perdí el tiempo, pues creo que nos educamos un poco, ya que me entere que hasta los caballos padecen de melanoma...si se trata de melanoma y cabello, escribame para buscar de nuevo en la red, saludos.

Hasta una proxima edición de DERMAGIC amigos de la DERMATO-CYBER-RED, saludos América Latina,,,

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DERMAGIC/EXPRESS(12)

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MELANOMA Y CABALLOS / MELANOMA AND HORSES 

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1.) Equine melanocytic tumors: a retrospective study of 53 horses (1988 to 1991).

2.) Clinical and pathological features of thoracic neoplasia in the horse.

3.) Morphogenesis of compound melanosomes in melanoma cells of a gray horse.

4.) Lesion thickness and prognosis in melanoma: horses are not zebras. A response to Green and Ackerman.

5.) The uptake of uridine in the nucleolus occurs in the dense fibrillar component. Immunogold localization of incorporated digoxigenin-UTP at the electron microscopic level.

6.) Ocular neoplasia.

7.) AN ESTIMATE OF MELANOSOME CONCENTRATION IN PIGMENT TISSUES

8.) Cutaneous melanomas in domestic animals.

9.) Benign and malignant melanocytic neoplasms of domestic animals.

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1.) Equine melanocytic tumors: a retrospective study of 53 horses (1988 to 1991).

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AU: Valentine-BA

AD: Department of Pathology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853-6401, USA.

SO: J-Vet-Intern-Med. 1995 Sep-Oct; 9(5): 291-7

ISSN: 0891-6640

PY: 1995

LA: ENGLISH

CP: UNITED-STATES

AB: A study of 57 cutaneous melanocytic tumors from 53 horses revealed 4 distinct clinical syndromes: melanocytic nevus, dermal melanoma, dermal melanomatosis, and anaplastic malignant melanoma. Melanocytic nevus and anaplastic melanoma each had histopathologic features that distinguished them from dermal melanoma and dermal melanomatosis. Dermal melanoma and dermal melanomatosis were histologically similar but could be differentiated by their clinical features. Melanocytic nevi were diagnosed in 29 horses with an average age of 5 years; they were solitary, superficial masses that occurred in both grey and nongrey horses, and in which surgical excision was generally curative. Dermal melanomas were diagnosed in 20 horses with an average age of 13 years; all horses of known coat color were grey. Eight horses with an average age of 7 years had 1 or 2 discrete dermal melanomas. Follow-up information was available for 6 horses; metastases occurred in 2 horses, and surgical excision was apparently curative in 4 horses. Dermal melanomatosis was diagnosed in 12 grey horses with an average age of 17 years; all 6 of these horses evaluated had internal metastases. In 2 aged nongrey horses with anaplastic malignant melanoma, the tumors metastasized within 1 year of diagnosis. Two tumors with features of both melanocytic nevus and dermal melanoma remained unclassified.

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2.) Clinical and pathological features of thoracic neoplasia in the horse.

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AU: Mair-TS; Brown-PJ

AD: Department of Veterinary Medicine, University of Bristol, School of Veterinary Science, Langford, UK.

SO: Equine-Vet-J. 25(3):220-3 1993

PY: 1993

LA: ENGLISH

PT: JOURNAL-ARTICLE

AB-A: Thirty-eight horses with confirmed thoracic neoplasia included 28 (37.7%) with lymphosarcoma, 4 (10.5%) with metastatic renal cell carcinoma, 2 (5.3%) with primary lung carcinoma, 2 (5.3%) with secondary squamous cell carcinoma from the stomach, 1 (2.6%) with pleural mesothelioma, and 1 (2.6%) with malignant melanoma. The major clinical features included weight loss, inappetence, dyspnoea and coughing, but in cases of lung metastases, they related more to the primary site of tumour formation. Haematological and serum biochemical abnormalities were non-specific. Specific pre-mortem diagnosis was made in 14 horses; this was most readily achieved when exfoliated neoplastic cells were present in pleural fluid. (Abstract from CANCERLIT)

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3.) Morphogenesis of compound melanosomes in melanoma cells of a gray horse.

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AU: Ohmuro-K; Okada-K; Satoh-A; Murakami-K; Satake-S; Asahina-M; Numakunai-S; Ohshima-K

AD: Department of Veterinary Pathology, Faculty of Agriculture, Iwate University, Morioka, Japan.

SO: J-Vet-Med-Sci. 55(4):677-80 1993

PY: 1993

LA: ENGLISH

PT: JOURNAL-ARTICLE

AB-A: A thoroughbred horse, gelding, gray color, aged 19 years old had cutaneous melanomas from the root to the middle of the tail, and throughout the connective tissues of the whole body. Histologically, the tumors were diagnosed as mature melanotic melanomas characteristically deposited with abundant melanin pigment. Examined with an electron microscope, melanosomes were electron opaque without internal structure (stage IV), or as mature granular and lamellar types. Most of them were fused with each other, and formed compound melanosomes, which was similar to internal melanin aggregates in shape. The internal melanin aggregates gradually disintegrated, and compound melanosomes grew spherical. The compound melanosomes changed into autophagosomes. (Abstract from CANCERLIT)

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4.) Lesion thickness and prognosis in melanoma: horses are not zebras. A response to Green and Ackerman.

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Green and Ackerman.

AU: Rigel-DS; Kopf-AW; Friedman-RJ

AD: Ronald O. Perelman Department of Dermatology, New York University Medical Center, New York.

SO: Am-J-Dermatopathol. 15(5):474-6 1993

PY: 1993

LA: ENGLISH

PT: JOURNAL-ARTICLE

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5.) The uptake of uridine in the nucleolus occurs in the dense fibrillar component. Immunogold localization of incorporated digoxigenin-UTP at the electron microscopic level.

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AU: Schofer-C; Muller-M; Leitner-MD; Wachtler-F

AD: Histologisch-Embryologisches Institut der Universitat, Vienna,Austria.

SO: Cytogenet-Cell-Genet. 64(1):27-30 1993

PY: 1993

LA: ENGLISH

PT: JOURNAL-ARTICLE

AB-A: A new method was developed to localize the site of transcription within the nucleolus. Incorporation of digoxigenin-labeled UTP in nucleoli of human PHA-stimulated lymphocytes and in equine melanoma cells was visualized with antibodies against digoxigenin and secondary gold-labeled antibodies at the electron-microscopic level. This approach offers much higher spatial resolution than the autoradiographic methods used so far. In both types of cells digoxigenin-UTP was incorporated mainly into the dense fibrillar component; the fibrillar centers, in contrast, did not display significant labeling above background levels. This finding corroborates the view that the dense fibrillar component is the site of RNA transcription in the nucleolus. (Abstract from CANCERLIT)

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6.) Ocular neoplasia.

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AU: Dugan-SJ

AD: Animal Eye Specialists, Phoenix, Arizona.

SO: Vet-Clin-North-Am-Equine-Pract. 8(3):609-26 1992

PY: 1992

LA: ENGLISH

PT: JOURNAL-ARTICLE; REVIEW; REVIEW,-TUTORIAL

AB-A: Except for two neoplasms, notably SCC and sarcoid, ocular and periocular tumors are uncommon in horses. The practitioner must accurately determine the type of tumor by histopathology so appropriate treatment and a legitimate prognosis can be offered. The first attempt at treatment has the greatest chance to result in a cure; an aggressive treatment regimen therefore should be selected from the start. (71 Refs) (Abstract from CANCERLIT)

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7.) AN ESTIMATE OF MELANOSOME CONCENTRATION IN PIGMENT TISSUES

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AU: Borovansky-J; Vedralova-E; Hach-P

AD: Department of Biochemistry, 1st Faculty of Medicine, Charles University, Prague, Czechoslovakia.

SO: Pigment-Cell-Res. 4(5-6):222-4 1991

PY: 1991

LA: ENGLISH

PT: JOURNAL-ARTICLE

AB-A: Concentration of melanosomes in various tissues has been unknown because of the impracticability of their direct quantification. Using an indirect approach comprising the estimation of melanin both in freeze-dried tissue samples and in isolated melanosomes, we obtained data on the amount of melanosomes in various pigment tissues. The concentrations of melanosomes found in the tissues were relatively high, not only reflecting the dark color of pigment tissues but also explaining their capacity to perform various functions ascribed to the presence of melanin. (Abstract from CANCERLIT)

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8.) - Cutaneous melanomas in domestic animals.

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SO - J Cutan Pathol 1981 Feb;8(1):3-24

AU - Garma-Avina A; Valli VE; Lumsden JH

MJ - Animals, Domestic; Melanoma [veterinary]; Skin Neoplasms [veterinary]

MN - Cat Diseases [pathology]; Cats; Cattle Diseases [pathology]; Cattle; Dog Diseases [pathology]; Dogs; Horse Diseases [pathology]; Horses; Melanoma [classification] [pathology]; Skin Neoplasms [classification] [pathology]; Species Specificity; Swine Diseases [pathology]; Swine

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9.) - Benign and malignant melanocytic neoplasms of domestic animals.

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SO - Am J Dermatopathol 1985;7 Suppl:203-12

AU - Goldschmidt MH

AD - School of Veterinary Medicine, Philadelphia, Pennsylvania.

MJ - Animals, Domestic; Melanoma [veterinary]; Skin Neoplasms [veterinary]

MN - Melanoma [pathology]; Skin Neoplasms [pathology]

MT - Animal

PT - JOURNAL ARTICLE; REVIEW (36 references); REVIEW, TUTORIAL

AB - Benign and malignant melanocytic neoplasms of domestic animals occur most commonly in the dog and horse. The classification, gross morphology, and histopathology of cutaneous, mucocutaneous, oral, and ocular melanocytic neoplasms in dogs is discussed herein, and the similarity of these neoplasms to those of man, horse, and Sinclair miniature swine is reviewed.

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DATA-MEDICOS/DERMAGIC-EXPRESS No (12) 02/11/98 DR. JOSE LAPENTA R. DERMATOLOGO

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